Botox Injections: Face & Back

Went to the VA hospital to see my Movement Disorder Specialist for my third attempt of Botox injections to solve my back pain and face spasms. 

Below is video of me getting injected about 14 times in my face and 20 times in my back. Please note the injections are pretty much painless. 

*The face shown here feels like small insect stings and may bleed slightly..

*The back was not painful at all due to the freezing spray they use first.

Since my  Deep Brain Stimulation last year on  July 12th  my Parkinson symptoms have been under control and in some cases *totally suppressed.. With the exception of  my *speech which has worsened as expected,

* DBS will rarely improve balance, prevent falls or enhance thinking or speech. 

Source: http://www.neurology.umn.edu/prod/groups/med/@pub/@med/documents/asset/med_32171.pdf

But the natural progression of my Parkinson disease has evidently continued. I have painful cervical dystonia (lower and upper back), a face spasm in my left cheek, and *Blepharospasm.  

*Blepharospasm is a muscle disorder that causes involuntary spasms of the muscles around your eye. These spasms can result in uncontrolled narrowing or closing of your eyelid. This could impair your vision, and make everyday tasks such as driving or using a computer difficult.

Sample of Blepharospasm

CASE SOLVED: Dark brown to amber urine

First le me apologize for my visual.  Yes it i urine in the toilet..my urine. I thought by psoting this unusual photo it may help somebody who is experienceing the same problem/scare that i did.

It turbn out that the water enhance rMio was turnin gmy urine dark bron to a light amber. I thought I was bleeding internally. My urologist took samples and set it toas lab and me to get a cat scan to lookffor kidney stones.

RESULTS: Labs& Cat Scan both turne dup negative. My urologist said it may be a medication or vitamin doing this.  I have been on SINEMET since 2000 and never haqd brown urine. I did take COMTAN which turns everything orange. Your mouth, hands, clothes, and yes your pee.

The only thuign that i could think of was the MIO Water Enhancer which has become popular.

I stopped drinking it for a few days and my urine rerturned to its normal coloration.  THne i started it again, and low and behold the enxt day i haad darkbron urine.
.

Young Onset Glaucoma?!..

I am starting to believe it is impossible for me to go to an appointment and not get bad news.

Early Onset Glaucoma:

Clogged tear ducts:

Bi-focals:

Eye test:

My trip to the Urologist...

My urology appointment began as a routine appointment which ended up as an odd adventure that could have ended badly.

I have had a spastic bladder for years as a symptom of my Parkinson's.  I had grown used to the difficult transition from boxers to diapers.  This was one of the most difficult PD related symptom that I have faced...until the "cervical dystonia" joined the line-up of diseases, symptoms, and side effects that is called "my life".  *See previous blog.

Changes to my body 10 days after Botox...

Before...

After..

*

Read the post on my first appointment for medical grade Botox injections on the 28th of January 2011. 

Seven days went by since my last Botox appoitment without any change to the horrible lower and upper back pains due to dystonia in my lower and upper back I started to become a bit disappointed. Then on the 8th day it happened. For the next 3 days I had picture perfect days. Virtually pain free, cramp free, I felt like a zillion dollars! Then yesterday a cold snap hit. My Parkinson's has always reacted badly to changes in the weather and this was a big change. The past two days the wires in my head have hurt, my lower back hurts and nothing sems to be working very well. I'm looking forward to the weather getting back to normal to see if that has an effect.

Dont get me wrong I would not chnae my DBS for all the money in the world! My MDS is wonderful andis giving me 150%. A huge hug for her from me!

Below are some random thoughts and last minute posts.

Parkinson's & Cervical Dystonia

Who knew Parkinson's disease was so easy!

Annoying Parkinson's Symptoms

I remember back in the good old days when I just had to deal with the annoying "symptoms" of Parkinson's disease. The slight tremor, the bradykenesia (slow movement), the muscle stiffness, and in my opinion the worst that Parkinson's brought to my life..the freezing episodes. 

Botox Fact & Fiction:

• Botox is a neurotoxin [neuro means nerve; toxin means poison] that temporarily paralyzes muscles in your face.
• Botox is derived from the same botulin toxin that is found in spoiled foods. Doctors use a sterile and purified form of this toxin when administering Botox injections.
• Botox injections cost up to $500 or more. The effects are not permanent. Over time, the body gradually absorbs the substance and the procedure must be repeated every 3-6 months.
• The FDA has approved Botox for use only on a limited area between the eyebrows. Botox is administered only for wrinkles and does not reduce other age-related symptoms such as age spots and facial discoloration.
• Improper injection has been linked to droopy eyelids. Other reported side effects include nausea fatigue, malaise, Flu and rashes.
• Botox is not recommended for pregnant women, women who are breastfeeding, people with neuromuscular disorders or cardiovascular disease.
• There have been no conclusive studies about the long-term side effects of Botox.

Botox Appointment

Sorry it took a few days for em to post this video and also sorry but I did not record the 10 or so face injections. The back is posted here for your viewing genjoyment



I will post details on this and the other items I missed plus details on my DBS operation as soon as I am able.

Optical Deep Brain Stimulation?

 University of Utah scientists used invisible infrared light to make rat heart cells contract and toadfish inner-ear cells send signals to the brain. The discovery someday might improve cochlear implants for deafness and lead to devices to restore vision, maintain balance and treat movement disorders like Parkinson's.
"We're going to talk to the brain with optical infrared pulses instead of electrical pulses," which now are used in cochlear implants to provide deaf people with limited hearing, says Richard Rabbitt, a professor of bioengineering and senior author of the heart-cell and inner-ear-cell studies published this month in The Journal of Physiology.
The studies – funded by the National Institutes of Health – also raise the possibility of developing cardiac pacemakers that use optical signals rather than electrical signals to stimulate heart cells. But Rabbitt says that because electronic pacemakers work well, "I don't see a market for an optical pacemaker at the present time."
The scientific significance of the studies is the discovery that optical signals – short pulses of an invisible wavelength of infrared laser light delivered via a thin, glass optical fiber – can activate heart cells and inner-ear cells related to balance and hearing.
In addition, the research showed infrared activates the heart cells, called cardiomyocytes, by triggering the movement of calcium ions in and out of mitochondria, the organelles or components within cells that convert sugar into usable energy. The same process appears to occur when infrared light stimulates inner-ear cells.

		IMAGE: Using an elaborate apparatus to study the inner-ear cells of the oyster toadfish (in clear plastic container, lower right), University of Utah bioengineering professor Richard Rabbitt found that infrared light... Click here for more information.

Infrared light can be felt as heat, raising the possibility the heart and ear cells were activated by heat rather than the infrared radiation itself. But Rabbitt and colleagues did "elegant experiments" to show the cells indeed were activated by the infrared radiation, says a commentary in the journal by Ian Curthoys of the University of Sydney, Australia.
Curthoys writes that the research provides "stunningly bright insight" into events within inner-ear cells and "has great potential for future clinical application."
Shedding Infrared Light on Inner-Ear Cells and Heart Cells
The low-power infrared light pulses in the study were generated by a diode – "the same thing that's in a laser pointer, just a different wavelength," Rabbitt says.
The scientists exposed the cells to infrared light in the laboratory. The heart cells in the study were newborn rat heart muscle cells called cardiomyocytes, which make the heart pump. The inner-ear cells are hair cells, and came from the inner-ear organ that senses motion of the head. The hair cells came from oyster toadfish, which are well-establish models for comparison with human inner ears and the sense of balance.
Inner-ear hair cells "convert the mechanical vibration from sound, gravity or motion into the signal that goes to the brain" via adjacent nerve cells, says Rabbitt.
Using infrared radiation, "we were stimulating the hair cells, and they dumped neurotransmitter onto the neurons that sent signals to the brain," Rabbitt says.
He believes the inner-ear hair cells are activated by infrared radiation because "they are full of mitochondria, which are a primary target of this wavelength."

		IMAGE: University of Utah bioengineer Rick Rabbitt uses a microscope in his laboratory to study how hearing- and balance-related cells in the inner ear transmit signals to the brain. Click here for more information.

The infrared radiation affects the flow of calcium ions in and out of mitochondria – something shown by the companion study in neonatal rat heart cells.
That is important because for "excitable" nerve and muscle cells, "calcium is like the trigger for making these cells contract or release neurotransmitter," says Rabbitt.
The heart cell study found that an infrared pulse lasting a mere one-5,000th of a second made mitochondria rapidly suck up calcium ions within a cell, then slowly release them back into the cell – a cycle that makes the cell contract.
"Calcium does that normally," says Rabbitt. "But it's normally controlled by the cell, not by us. So the infrared radiation gives us a tool to control the cell. In the case of the [inner-ear] neurons, you are controlling signals going to the brain. In the case of the heart, you are pacing contraction."


New Possibilities for Optical versus Electrical Cochlear Implants
Rabbitt believes the research – including a related study of the cochlea last year – could lead to better cochlear implants that would use optical rather than electrical signals.
Existing cochlear implants convert sound into electrical signals, which typically are transmitted to eight electrodes in the cochlea, a part of the inner ear where sound vibrations are converted to nerve signals to the brain. Eight electrodes can deliver only eight frequencies of sound, Rabbitt says.
"A healthy adult can hear more than 3,000 different frequencies. With optical stimulation, there's a possibility of hearing hundreds or thousands of frequencies instead of eight. Perhaps someday an optical cochlear implant will allow deaf people to once again enjoy music and hear all the nuances in sound that a hearing person would enjoy."
Unlike electrical current, which spreads through tissue and cannot be focused to a point, infrared light can be focused, so numerous wavelengths (corresponding to numerous frequencies of sound) could be aimed at different cells in the inner ear.
Nerve cells that send sound signals from the ears to the brain can fire more than 300 times per second, so ideally, a cochlear implant using infrared light would be able to perform as well. In the Utah experiments, the researchers were able to apply laser pulses to hair cells to make adjacent nerve cells fire up to 100 times per second. For a cochlear implant, the nerve cells would be activated within infrared light instead of the hair cells.
Rabbitt cautioned it may be five to 10 years before the development of cochlear implants that run optically. To be practical, they need a smaller power supply and light source, and must be more power efficient to run on small batteries like a hearing aid.


Optical Prosthetics for Movement, Balance and Vision Disorders
Electrical deep-brain stimulation now is used to treat movement disorders such as Parkinson's disease and "essential tremor, which causes rhythmic movement of the limbs so it becomes difficult to walk, function and eat," says Rabbitt.
He is investigating whether optical rather than electrical deep-brain stimulation might increase how long the treatment is effective.
Rabbitt also sees potential for optical implants to treat balance disorders.
"When we get old, we shuffle and walk carefully, not because our muscles don't work but because we have trouble with balance," he says. "This technology has potential for restoring balance by restoring the signals that the healthy ear sends to the brain about how your body is moving in space."
Optical stimulation also might provide artificial vision in people with retinitis pigmentosa or other loss of retinal cells – the eye cells that detect light and color – but who still have the next level of cells, known as ganglia, Rabbitt says.
"You would wear glasses with a camera [mounted on the frames] and there would be electronics that would convert signals from the camera into pulses of infrared radiation that would be patterned onto the diseased retina that normally does not respond to light but would respond to the pulsed infrared radiation" to create images, he says.
Hearing and vision implants that use optical rather than electrical signals do not have to penetrate the brain or other nerve tissue because infrared light can penetrate "quite a bit of tissue," so devices emitting the light "have potential for excellent biocompatibility," Rabbitt says. "You will be able to implant optical devices and leave them there for life."

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The heart cell study was led by Rabbitt, with University of Utah bioengineering doctoral student Gregory Dittami as first author. Co-authors were Suhrud Rajguru, a former Utah doctoral student now at Northwestern University in Chicago; Utah doctoral student Richard Lasher; and Robert Hitchcock, an assistant professor of bioengineering at the University of Utah.
Rabbitt's coauthors on the inner-ear study included first author Rajguru; Dittami; Claus-Peter Richter and Agnella Matic of Northwestern University; neuroscientist Gay Holstein of Mount Sinai School of Medicine in New York; and neuroscientist Stephen Highstein of the Marine Biological Laboratory in Woods Hole, Mass.
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